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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10644 | c-Fms-IN-10 | Others | |
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity. | |||
T6930 | Pazopanib Hydrochloride | GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala | c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy |
Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp... | |||
T2668 | JNK-IN-8 | JNK Inhibitor XVI | JNK , c-Kit |
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line. | |||
T0097L | Pazopanib | GW786034 | VEGFR , FGFR , PDGFR , c-Kit , Autophagy |
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i... | |||
T10645 | c-Fms-IN-6 | c-Fms | |
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM). |